Hypertensive Disorders of Pregnancy

Pathophysiology

Increased vascular reactivity-

Increased platelet activation

Alterations are seen in nearly every system:

Hematologic

Thrombocytopenia, hemolysis, increased platelet activation

Cardiovascular

Vasospasm, hemoconcentration

Renal

Proteinuria, oliguria, ATN, acute renal failure

Hepatic

Elevated transaminases, hyperbilirubinemia, hepatic hemorrhage

Neurologic

Headache, scotomata, blurred vision, hyperreflexia, temporary blindness, seizures.

Fetoplacental

IUGR, oligohydramnios, abruption, impaired gas exchange, nonreassuring fetal status